Treating Cancer

From notebook

Latest revision as of 08:34, 23 September 2016

I have not been diagnosed with cancer, but I had reason to think about the future of treatment for metastatic cancer.

A while back a guy I knew from Edinburgh got metastatic bowel cancer.

I started out from the Lance Armstrong effect - testicular cancer, even stage 4, can be cured because testicular cells are weak. There is even a suggestion that the fact that he cycled around Texas shortly after his surgery helped to kill the weak testicular cancers, by heat. http://jama.jamanetwork.com/article.aspx?articleid=211135

And also, there is nothing knew under the sun so I went from traditional Japanese therapies which focus on heat in the form of moxibustion (灸) and hot stones (岩盤浴).

A Japanese folk cure for cancer is lying on hot stones at spas.

Heat to cure warts http://informahealthcare.com/doi/abs/10.3109/02656736.2012.677929?journalCode=hth Radiation therapy and Heath therapy http://informahealthcare.com/doi/abs/10.3109/02656736.2015.1033482

Using these facts as a starting point.......

Most hypathermia treatments use ultrasound, Microwaves and Radio waves for short periods of time, but they seem to be using the sort of temperatures that could be transfered by via the skin for longer periods of time (if one could bear the pain). http://cancerres.aacrjournals.org/content/44/10_Supplement/4745s.short

In the 1990s Hyperthermia was nearly doubling the effectiveness of irradiation (but not working so well with Chemo) https://goo.gl/OIdCtr

Hyperthermia better in later stage cancer. http://www.tandfonline.com/doi/abs/10.3109/02656739009140944

Hypothermia plus radiation results in improved HNSCC survival rates http://www.sciencedirect.com/science/article/pii/0360301694901546 Conclusion This 5-year analysis on a Phase III randomized trial comparing conventionally fractionated radical radiation with radical radiation plus hyperthermia to metastatic neck nodes in a Stage IV group of patients demonstrates that the combined treatment: (1) Significantly improves actuarial nodal control:(2) Significantly improves 5-year actuarial survival; and (3) does not increase acute toxicity and does not significantly affect late toxicity. Considering the limited number of patients treated, further randomized trials are needed to support these observations.

Shorty term trial by the same authors concluded “The results of this report demonstrate the advantage of adding hyperthermia to conventionally fractionated radical irradiation without an increase in acute irradiation side effects in a group of patients with fixed N3 TNM-UICC) squamous cell neck nodes.

Trouble is, "Heat Shock Proteins", http://en.wikipedia.org/wiki/Heat_shock_protein which protect cells from heat (and chemo) by hardening and "chaperoning" damaged cellular matter to the trash, are prevalent in cancer cells. They are obviously not prevalent enough in testicular cells, but other forms of cancer are protected enough to survive heat shock and chemo, perhaps due to the "over expression" of these protective rubbish-dump-chaperoning proteins.

There has been some research to "silence" these Heat Shock protector cells and then use heat, or chemo to kill the cancer cells which started in Japan (I think). http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2006.00217.x/full

Particularly the Heat shock protein HSP)0 https://en.wikipedia.org/wiki/Hsp90_inhibitor

Heat Shock Gene silencers can be purchased online. http://www.scbt.com/sirna/table-apg_heat_shock_protein.html

The same Small Interfering RNAs can be used to attack cancers directly http://clincancerres.aacrjournals.org/content/9/4/1291.long

but I like the idea of attacking the heat protectors and then using another method of attack.

There are natural Heat Shock Protein suppressors eg. geldanamycin novolactone Radicicol But they are in rare natural molecules, and toxic.

"Thunder God Vine" used in Chinese herbal remedies https://en.wikipedia.org/wiki/Tripterygium is a heat shock protein inhibitor https://goo.gl/B9l1S3 But toxic http://www.acupuncturetoday.com/archives2004/jan/01chen.html

Burdock (Gobou 牛蒡) https://en.wikipedia.org/wiki/Arctium A component of Burdock worked as a heat shock protein suppressor http://www.bioone.org/doi/abs/10.1379/CSC-148R.1 Thus, arctigenin seemed to be a new suppressive regulator of heat shock response in mammalian cells, and may be useful for hyperthermia cancer therapy.

Quercetin https://en.wikipedia.org/wiki/Quercetin Which is in red kidney beans (chili) the most.

Coumarin found in some types of Cinnamon https://en.wikipedia.org/wiki/Coumarin has some toxicity. https://en.wikipedia.org/wiki/Cinnamomum_cassia

Curcumin in Tumeric suppresses heat shock proteins

The

This http://jco.ascopubs.org/content/27/16/2712.full

Trouble is, cancers are over-protected against heat shock so to an extent, unless one can localise the heat, it would be like using a grenade to kill a bad guy who is the only person wearing a bullet proof vest, in a room full of hostages. However, there is some more recent research that finds that cancerous cells also contain a mutant heat shock protein and this mutant gets in the way of the protective function.

"Developing inhibitors of HSP110 that mimic the anti-cancer chemosensitizing effect of HSP110DE9 is also a promising perspective"

But I don't see this conclusion. If an inhibitor were produced then it would presumably inhibit all the heat shock proteins of everyone in the room. If there were somewhat of promoting the replication of the mutant protein however, it would only affect those cells that had the mutant heat shock protecting protein. I would be like getting the covering of his bullet proof vest to froth so that he has to take off all this clothes. Is there a way of activating "HSP110DE9" I wonder.