Treating Cancer

From notebook

Revision as of 02:27, 17 June 2013

I have not been diagnosed with cancer, but I had reason to think about the future of treatment for metastatic cancer.

I started out from the Lance Armstrong effect - testicular cancer, even stage 4, can be cured because testicular cells are weak.

There is even a suggestion that the fact that he cycled around Texas shortly after his surgery helped to kill the weak testicular cancers, by heat. http://jama.jamanetwork.com/article.aspx?articleid=211135

A Japanese folk cure for cancer is lying on hot stones at spas.

Using these facts as a starting point.......

Trouble is, "Heat Shock Proteins", http://en.wikipedia.org/wiki/Heat_shock_protein which protect cells from heat (and chemo) by hardening and "chaperoning" damaged cellular matter to the trash, are prevalent in both testicular cells and cancer cells. They are obviously not prevalent enough in testicular cells, but other forms of cancer are protected enough to survive heat shock and chemo, perhaps due to the "over expression" of these protective rubbish-dump-chaperoning proteins.

There has been some research to "silence" these Heat Shock protector cells and then use heat, or chemo to kill the cancer cells which started in Japan (I think). http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2006.00217.x/full

Heat Shock Gene silencers can be purchased online. http://www.scbt.com/sirna/table-apg_heat_shock_protein.html

The same Small Interfering RNAs can be used to attack cancers directly http://clincancerres.aacrjournals.org/content/9/4/1291.long

but I liked the idea of attacking the heat protectors and then using another method of attack.

Trouble is, if cancers are over-protected, then, it would be like using a grenade to kill a bad guy who is the only person wearing a bullet proof vest, in a room full of hostages.

However, there is some more recent research that finds that cancerous colorectal cells also contain a mutant the heat shock protein and this mutant gets in the way of the protective function. http://www.nature.com/nm/journal/v17/n10/full/nm.2457.html http://www.nature.com/nm/journal/v17/n10/full/nm.2500.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259994/

Two of these papers say

"In the future, designing small peptides that mimic the sensitizing function of HSP110ΔE9 and could therefore be readily adapted to improve the treatment of both MSI and MSS tumors may constitute viable therapeutic strategies."

"Developing inhibitors of HSP110 that mimic the anti-cancer chemosensitizing effect of HSP110DE9 is also a promising perspective"

But I don't see this conclusion. If an inhibitor were produced then it would presumably inhibit all the heat shock proteins of everyone in the room.

If there were somewhat of promoting the replication of the mutant protein however, it would only affect those cells that had the mutant heat shock protecting protein.

I would be like getting the covering of his bullet proof vest to froth so that he has to take off all this clothes.

Is there a way of activating "HSP110DE9"